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J Clin Periodontol. 2014 Feb;41(2):131-40. doi: 10.1111/jcpe.12192. Epub 2013 Dec 10.

Number of teeth, C-reactive protein, fibrinogen and cardiovascular mortality: a 15-year follow-up study in a Finnish cohort.

Author information

1
Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, USA.

Abstract

AIM:

To test whether the number of teeth, an inverse proxy for composite oral infection scores is associated with better survival.

MATERIALS AND METHODS:

The Kuopio Oral Health and Heart study initiated a case-control study in 1995-1996 consisting of 256 consecutive coronary artery disease patients and 250 age and gender-matched controls. We appended the mortality data and formulated a longitudinal study. By May 31st, 2011, 124 mortalities had occurred and 80 of which were of cardiovascular origin. Using Cox proportional hazards models, we assessed the association of the teeth group (Teethgrp) - consisting of 10 teeth - with cardiovascular and all-cause mortality after 15.8 years of median follow-up.

RESULTS:

In multivariate models, with the edentulous state as reference, one level increase in Teethgrp was associated with significantly increased survival from cardiovascular disease (CVD) mortality with a Hazard Ratio (HR) 0.73, p-value = 0.02 but not with all-cause mortality (HR = 0.87, p = 0.13). The findings were not mediated by C-reactive protein (CRP) levels ≥3 mg/L or by median fibrinogen levels, but were mediated by CRP levels >5 mg/L.

CONCLUSION:

Each increment of 10 teeth from the edentulous state was associated with a 27% improved CVD survival, independent of low-grade systemic inflammation.

KEYWORDS:

C-reactive protein; CVD mortality; fibrinogen; mediation analyses; number of teeth

PMID:
24354534
PMCID:
PMC3934352
DOI:
10.1111/jcpe.12192
[Indexed for MEDLINE]
Free PMC Article

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