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J Nat Prod. 2014 Jan 24;77(1):9-14. doi: 10.1021/np4004799. Epub 2013 Dec 19.

Dioxatricyclic and oxabicyclic polyketides from Trichocladium opacum.

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1
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100190, People's Republic of China.

Abstract

Five new polyketides, trichocladinols D-H (1-5) with dioxatricyclic (1-3) and oxabicyclic (4 and 5) skeletons, and the known massarilactone C (6) were isolated from the solid-substrate fermentation cultures of the ascomycete fungus Trichocladium opacum. The structures of 1-5 were determined mainly by NMR experiments, and 1, 3, and 4 were confirmed by X-ray crystallography. The absolute configurations of 1 and 3 were assigned by X-ray crystallography using Cu Kα radiation, whereas that of C-5 in 2 and 4 was deduced via the circular dichroism (CD) data. Compounds 2-4 showed weak cytotoxicity against the human tumor cell lines A549, HCT116, and SW480.

PMID:
24354429
DOI:
10.1021/np4004799
[Indexed for MEDLINE]
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