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Nat Prod Commun. 2013 Oct;8(10):1393-6.

Alkaloids from an endophytic streptomyces sp. YIM66017.

Author information

1
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
2
Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, China.

Abstract

Three alkaloids, flavensomycinoic acid (1), a linear polyketide, alpiniamide (2), and cyclo (L-Trp-L-Ala) (3), were isolated from the culture filtrate of endophytic Streptomyces sp. YIM66017 from Alpinia oxyphylla. Their structures were elucidated by spectroscopic analysis and the structure of 1 was confirmed by X-ray crystallographic analysis. Compound 1 was isolated from a natural source for the first time, and compound 2 is a new compound. Compound 1 showed cytotoxicity to MCF-7 with an IC50 value of 17.0 microM.

PMID:
24354182
[Indexed for MEDLINE]
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