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J Immunol. 2014 Feb 1;192(3):1079-90. doi: 10.4049/jimmunol.1301657. Epub 2013 Dec 18.

PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.

Author information

1
Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115.

Abstract

Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Repeated infections with C. trachomatis lead to serious sequelae, such as infertility. It is unclear why the adaptive immune system, specifically the CD8(+) T cell response, is unable to protect against subsequent C. trachomatis infections. In this article, we characterize the mucosal CD8(+) T cell response to C. trachomatis in the murine genital tract. We demonstrate that the immunoinhibitory ligand, PD-L1, contributes to the defective CD8(+) T cell response. Deletion or inhibition of PD-L1 restores the CD8(+) T cell response and enhances C. trachomatis clearance.

PMID:
24353266
PMCID:
PMC3921669
DOI:
10.4049/jimmunol.1301657
[Indexed for MEDLINE]
Free PMC Article

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