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Cell Biol Int. 2014 Apr;38(4):526-30. doi: 10.1002/cbin.10228. Epub 2014 Jan 10.

(+)-Catechin attenuates activation of hepatic stellate cells.

Author information

1
Laboratório de Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Abstract

(+)-Catechin is a type of catechin present in large amounts in açaí fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor γ mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.

KEYWORDS:

catechin; hepatic stellate cell; inflammation; liver fibrosis; peroxisome proliferator-activated receptor γ; type I collagen

PMID:
24353036
DOI:
10.1002/cbin.10228
[Indexed for MEDLINE]

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