Format

Send to

Choose Destination
Genes Dev. 2013 Dec 15;27(24):2615-27. doi: 10.1101/gad.229724.113.

Hallmarks of a new era in mitochondrial biochemistry.

Author information

1
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA;

Abstract

Stemming from the pioneering studies of bioenergetics in the 1950s, 1960s, and 1970s, mitochondria have become ingrained in the collective psyche of scientists as the "powerhouses" of the cell. While this remains a worthy moniker, more recent efforts have revealed that these organelles are home to a vast array of metabolic and signaling processes and possess a proteomic landscape that is both highly varied and largely uncharted. As mitochondrial dysfunction is increasingly being implicated in a spectrum of human diseases, it is imperative that we construct a more complete framework of these organelles by systematically defining the functions of their component parts. Powerful new approaches in biochemistry and systems biology are helping to fill in the gaps.

KEYWORDS:

biochemistry; mitochondria; proteomics

PMID:
24352419
PMCID:
PMC3877752
DOI:
10.1101/gad.229724.113
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center