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Nat Immunol. 2014 Jan;15(1):15-25. doi: 10.1038/ni.2785.

NF-κB control of T cell development.

Author information

1
The Australian Centre for Blood Diseases and Department of Clinical Hematology, Monash University Central Clinical School, Melbourne, Victoria, Australia.

Abstract

The NF-κB signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-κB controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals.

PMID:
24352326
DOI:
10.1038/ni.2785
[Indexed for MEDLINE]
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