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Molecules. 2013 Dec 16;18(12):15724-36. doi: 10.3390/molecules181215724.

Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation.

Author information

1
Biospectrum Life Science Institute, Eines Platz 11th FL, 442-13 Sangdaewon Dong, Seongnam City, 462-807 Gyunggi Do, Korea. pdh@biospectrum.com.

Abstract

Madecassoside (MA), a pentacyclic triterpene isolated from Centella asitica (L.), is used as a therapeutic agent in wound healing and also as an anti-inflammatory and anti-aging agent. However, the involvement of MA in skin-pigmentation has not been reported. This study was conducted to investigate the effects of MA on ultraviolet (UV)-induced melanogenesis and mechanisms in a co-culture system of keratinocytes and melanocytes. MA significantly inhibited UVR-induced melanin synthesis and melanosome transfer in the co-culture system. These effects were further demonstrated by the MA-induced inhibition of protease-activated receptor-2 expression and its signaling pathway, cyclooxygenase-2, prostaglandin E2 and prostaglandin F2 alpha in keratinocytes. The clinical efficacy of MA was confirmed on artificially tanned human skin. MA significantly reduced UV-induced melanin index at 8 weeks after topical application. Overall, the study demonstrated significant benefits of MA use in the inhibition of hyperpigmentation caused by UV irradiation.

PMID:
24352025
PMCID:
PMC6290557
DOI:
10.3390/molecules181215724
[Indexed for MEDLINE]
Free PMC Article

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