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Viruses. 2013 Dec 16;5(12):3192-212. doi: 10.3390/v5123192.

Make yourself at home: viral hijacking of the PI3K/Akt signaling pathway.

Author information

1
Universitätsklinikum Düsseldorf, Institut für Virologie, Universitätsstraße 1, Düsseldorf 40225, Germany. schaal@uni-duesseldorf.de.

Abstract

As viruses do not possess genes encoding for proteins required for translation, energy metabolism or membrane biosynthesis, they are classified as obligatory intracellular parasites that depend on a host cell to replicate. This genome limitation forces them to gain control over cellular processes to ensure their successful propagation. A diverse spectrum of virally encoded proteins tackling a broad spectrum of cellular pathways during most steps of the viral life cycle ranging from the host cell entry to viral protein translation has evolved. Since the host cell PI3K/Akt signaling pathway plays a critical regulatory role in many cellular processes including RNA processing, translation, autophagy and apoptosis, many viruses, in widely varying ways, target it. This review focuses on a number of remarkable examples of viral strategies, which exploit the PI3K/Akt signaling pathway for effective viral replication.

PMID:
24351799
PMCID:
PMC3967167
DOI:
10.3390/v5123192
[Indexed for MEDLINE]
Free PMC Article

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