Format

Send to

Choose Destination
Cancer Biol Ther. 2014 Mar 1;15(3):342-9. doi: 10.4161/cbt.27328. Epub 2013 Dec 18.

Alterations of high endothelial venules in primary and metastatic tumors are correlated with lymph node metastasis of oral and pharyngeal carcinoma.

Author information

1
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education; Wuhan University; Wuhan, PR China.
2
Department of Oral and Maxillofacial Surgery; Wuhan General Hospital of Guangzhou Military Command; Wuhan, PR China.
3
First Department of Oral and Maxillofacial-Head and Neck Oncology; School and Hospital of Stomatology; Wuhan University; Wuhan, PR China.
4
The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory for Oral Biomedicine Ministry of Education; Wuhan University; Wuhan, PR China; First Department of Oral and Maxillofacial-Head and Neck Oncology; School and Hospital of Stomatology; Wuhan University; Wuhan, PR China.

Abstract

High endothelial venules (HEVs) are special blood vessels in the paracortical region of lymph nodes (LNs) and govern lymphocyte recruitment. LN metastasis has similarity to circulating lymphocytes homing to LNs, but the role of HEVs in the progression of oral and pharyngeal squamous cell carcinoma (OPSCC) is unclear. In this study, we found that HEVs experienced a series of morphological and functional changes during OPSCC progression and were correlated with LN metastasis. In 9 cases of 73 metastatic LNs, tumor emboli were located adjacent to HEVs or just out of the vessels but not lymphatic channels. Gap junctions of tumor cells close to HEVs decreased or disappeared, and gaps were left at contact points where tumor cells attached to the HEVs. Moreover, the proliferation rate of endothelial cells of HEVs was the highest in metastatic LNs. Finally, L-selectin was detected in both primary and metastatic tumors, and it facilitated tumor cells adhering to LNs. In conclusion, our findings suggest that remodeled HEVs are correlated with LN metastasis of OPSCC and play important role in this process by preparing premetastatic soil for cancer cell metastasis.

KEYWORDS:

L-selectin; high endothelial venules; lymph nodes; metastasis; oral and pharyngeal squamous cell carcinoma

PMID:
24351553
PMCID:
PMC3974835
DOI:
10.4161/cbt.27328
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center