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PLoS One. 2013 Dec 12;8(12):e83218. doi: 10.1371/journal.pone.0083218. eCollection 2013.

Identification of putative target genes of the transcription factor RUNX2.

Author information

1
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.

Abstract

Comparisons of the genomes of Neandertals and Denisovans with present-day human genomes have suggested that the gene RUNX2, which encodes a transcription factor, may have been positively selected during early human evolution. Here, we overexpress RUNX2 in ten human cell lines and identify genes that are directly or indirectly affected by RUNX2 expression. We find a number of genes not previously known to be affected by RUNX2 expression, in particular BIRC3, genes encoded on the mitochondrial genome, and several genes involved in bone and tooth formation. These genes are likely to provide inroads into pathways affected by RUNX2 and potentially by the evolutionary changes that affected RUNX2 in modern humans.

PMID:
24349465
PMCID:
PMC3861491
DOI:
10.1371/journal.pone.0083218
[Indexed for MEDLINE]
Free PMC Article

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