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PLoS One. 2013 Dec 12;8(12):e83123. doi: 10.1371/journal.pone.0083123. eCollection 2013.

The clinical value of Huangqi injection in the treatment of leucopenia: a meta-analysis of clinical controlled trials.

Author information

1
Department of Oncology, Changzhou Tumor Hospital Soochow University, Changzhou, China.
2
Department of Oncology, Changzhou Tumor Hospital Soochow University, Changzhou, China ; Department of Laboratory Medicine, Changzhou Tumor Hospital Soochow University, Changzhou, China.
3
Department of Radiation Oncology, Changzhou Tumor Hospital Soochow University, Changzhou, China.
4
Department of Laboratory Medicine, Changzhou Tumor Hospital Soochow University, Changzhou, China.

Abstract

BACKGROUND:

Huangqi injection is derived from Astragalus membranaceus root. In China, recent reports of Huangqi injection for the treatment of leucopenia have emerged. However, a systematic review of these reports has not been performed. Thus, we conducted a meta-analysis of clinical controlled trials to assess the clinical value of Huangqi injection in the treatment of leucopenia.

METHODS:

We searched the Chinese Biomedical Literature Database (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), Chinese Scientific Journals Full-text Database (VIP), as well as PubMed and EMBASE to collect the data about trials of Huangqi injection for treating leucopenia. A meta-analysis was performed using RevMan 5.2 software.

RESULTS:

A total of 13 studies involving 841 patients were included in this study. The overall study quality was lower according to the Jadad scale. The meta-analysis showed that experimentally treated patients experienced greater therapeutic efficacy and lower white blood cell counts than control groups treated with Western medicine (P < 0.05). No publication bias was evident, according to Egger's test.

CONCLUSIONS:

The validity of this meta-analysis was limited by the overall poor quality of the included studies. Huangqi injection may have potential clinical value in the treatment of leucopenia, but confirmation with rigorously well-designed multi-center trials is needed.

PMID:
24349444
PMCID:
PMC3861487
DOI:
10.1371/journal.pone.0083123
[Indexed for MEDLINE]
Free PMC Article

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