Abstract
A pilot study was performed in order to determine if filtration bleb longevity could be enhanced in rabbits by delivery of 5-fluorouracil or bleomycin in a collagen sponge implant. Results showed that both agents prolonged bleb longevity and lowered intraocular pressure when compared to controls. Bleomycin treated animals had the best bleb appearance and function at the longest postoperative intervals.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Bleomycin / administration & dosage*
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Bleomycin / therapeutic use
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Cell Division / drug effects
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Collagen*
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Drug Implants
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Eye / pathology
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Female
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Fibroblasts / cytology
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Fibroblasts / drug effects
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Fluorouracil / administration & dosage*
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Fluorouracil / therapeutic use
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Glaucoma / surgery*
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Intraocular Pressure / drug effects
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Male
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Pilot Projects
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Postoperative Care
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Rabbits
Substances
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Drug Implants
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Bleomycin
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Collagen
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Fluorouracil