Format

Send to

Choose Destination
See comment in PubMed Commons below
Iran J Radiol. 2013 Sep;10(3):128-32. doi: 10.5812/iranjradiol.11336. Epub 2013 Aug 30.

Magnetic resonance spectroscopic findings of chronic lesions in two subtypes of multiple sclerosis: primary progressive versus relapsing remitting.

Author information

  • 1Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
  • 2Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Medical Physics and Biomedical Engineering Department, Tehran University of Medical Sciences, Tehran, Iran.
  • 3Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
  • 4Department of Radiology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • 5Community Medicine Department, Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

Multiple sclerosis (MS) is a highly prevalent cause of neurological disability and has different clinical subtypes with potentially different underlying pathologies. Differentiation of primary progressive multiple sclerosis (PPMS) from relapsing remitting multiple sclerosis (RRMS) could be difficult especially in its early phases.

OBJECTIVES:

We compared brain metabolite concentrations and ratios in patients with PPMS and RRMS by magnetic resonance spectroscopic imaging (MRSI).

PATIENTS AND METHODS:

Thirty patients with definite MS (15 with RRMS and 15 with PPMS) underwent MRSI and their non-enhancing lesion metabolites were measured. N-acetyl aspartate (NAA), Creatine (Cr), Choline (Cho), NAA/Cr and NAA/Cho were measured and compared between the two MS subtypes.

RESULTS:

When the two MS groups were compared together, we found that Cr was significantly increased (P value=0.008) and NAA/Cr was significantly decreased (P value=0.03) in non-enhancing lesions in PPMS compared with RRMS. There was no significant difference in NAA, Cho or NAA/Cho between the two MS subtypes.

CONCLUSION:

MRS is a potential way to differentiate PPMS and RRMS.

KEYWORDS:

Magnetic Resonance Spectroscopy; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting

PMID:
24348597
PMCID:
PMC3857974
DOI:
10.5812/iranjradiol.11336
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center