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Pharmacogn Rev. 2013 Jul;7(14):121-30. doi: 10.4103/0973-7847.120511.

Cholinesterase inhibitors from botanicals.

Author information

1
Indian Institute of Crop Processing Technology, Ministry of Food Processing Industries, Government of India, Thanjavur, India.
2
Department of Chemistry, Kulliyyah of Science, IIUM, Kuantan, Malaysia.
3
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Kingdom of Saudi Arabia.

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease, wherein a progressive loss of cholinergic synapses occurs in hippocampus and neocortex. Decreased concentration of the neurotransmitter, acetylcholine (ACh), appears to be critical element in the development of dementia, and the most appropriate therapeutic approach to treat AD and other form of dementia is to restore acetylcholine levels by inhibiting both major form of cholinesterase: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Consequently, researches have focused their attention towards finding cholinesterase inhibitors from natural products. A large number of such inhibitors have been isolated from medicinal plants. This review presents a comprehensive account of the advances in field of cholinesterase inhibitor phytoconstituents. The structures of some important phytoconstituents (collected through www.Chemspider.com) are also presented and the scope for future research is discussed.

KEYWORDS:

Acetylcholinesterase; alkaloids; alzheimer's disease; butyrylcholinesterase; buxaceae

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