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Hum Exp Toxicol. 2014 Oct;33(10):1017-39. doi: 10.1177/0960327113515504. Epub 2013 Dec 17.

Environmental toxins: alarming impacts of pesticides on male fertility.

Author information

1
Department of Physiology, Vidyasagar College for Women, University of Calcutta, Kolkata, West Bengal, India sunny_pallav_1984@yahoo.co.in.
2
Department of Physiology, University of Calcutta, Kolkata, West Bengal, India.

Abstract

This review comprehensively summarizes the effects of more than 15 mostly used pesticides on male reproductive physiology, as recent experimental and epidemiological research have indicated their alarming impact on overall human health. Mechanisms have described that pesticide exposure damages spermatozoa, alter Sertoli or Leydig cell function, both in vitro and in vivo and thus affects semen quality. But, the literature suggests a need for more intricate research in those pesticides that are defined as mutagens or carcinogens and directly affect the hypothalamic-pituitary-gonadal axis. This literature review also proposes specific solutions to overcome these health effects.

KEYWORDS:

Infertility; in vivo; oligozoospermic; pesticides; sperm quality

PMID:
24347299
DOI:
10.1177/0960327113515504
[Indexed for MEDLINE]
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