Format

Send to

Choose Destination
See comment in PubMed Commons below
Development. 2014 Jan;141(1):5-9. doi: 10.1242/dev.094805.

Sphingosine 1-phosphate signalling.

Author information

1
Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

Abstract

Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.

KEYWORDS:

S1P receptors; Sphingomyelin; Sphingosine-1-phosphate

PMID:
24346695
PMCID:
PMC3865745
DOI:
10.1242/dev.094805
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center