Format

Send to

Choose Destination
Nat Commun. 2013;4:2928. doi: 10.1038/ncomms3928.

Phylogenetic applications of whole Y-chromosome sequences and the Near Eastern origin of Ashkenazi Levites.

Author information

1
1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2].
2
1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2] Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel [3].
3
Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia.
4
Department of Psychiatry, Stanford University, Stanford, California 94305, USA.
5
Ancestry.com DNA, Provo, Utah 84604, USA.
6
Department of Bioengineering, Stanford University, Stanford, California 94305, USA.
7
Program in Biomedical Informatics and Department of Statistics, Stanford University, Stanford, California 94305, USA.
8
Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel.
9
1] Estonian Biocentre and Department of Evolutionary Biology, University of Tartu, Tartu 51010, Estonia [2] Laboratory of Ethnogenomics, Institute of Molecular Biology, National Academy of Sciences, Yerevan 0014, Armenia.
10
Department of Statistics and Operations Research, School of Mathematical Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
11
Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia 27100, Italy.
12
1] Dipartimento di Biologia e Biotecnologie 'Lazzaro Spallanzani', Università di Pavia, Pavia 27100, Italy [2] Centro Interdipartimentale 'Studi di Genere', Università di Pavia, Pavia 27100, Italy.
13
Department of Genetics, Stanford University, Stanford, California 94305, USA.
14
1] Molecular Medicine Laboratory, Rambam Health Care Campus, Haifa 31096, Israel [2] Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel.
15
Division of Biological Anthropology, University of Cambridge, CB2 3QG Cambridge, UK.

Abstract

Previous Y-chromosome studies have demonstrated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a distinctive founder event within R1a, the most prevalent Y-chromosome haplogroup in Eastern Europe. Here we report the analysis of 16 whole R1 sequences and show that a set of 19 unique nucleotide substitutions defines the Ashkenazi R1a lineage. While our survey of one of these, M582, in 2,834 R1a samples reveals its absence in 922 Eastern Europeans, we show it is present in all sampled R1a Ashkenazi Levites, as well as in 33.8% of other R1a Ashkenazi Jewish males and 5.9% of 303 R1a Near Eastern males, where it shows considerably higher diversity. Moreover, the M582 lineage also occurs at low frequencies in non-Ashkenazi Jewish populations. In contrast to the previously suggested Eastern European origin for Ashkenazi Levites, the current data are indicative of a geographic source of the Levite founder lineage in the Near East and its likely presence among pre-Diaspora Hebrews.

PMID:
24346185
PMCID:
PMC3905698
DOI:
10.1038/ncomms3928
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center