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Int J Dev Neurosci. 2014 Apr;33:57-61. doi: 10.1016/j.ijdevneu.2013.12.002. Epub 2013 Dec 15.

Maternal serum AGEs levels in pregnancies associated with neural tube defects.

Author information

1
Laboratory for Development, College of Life Sciences, Northwest University, Taibai west road 229#, Shaanxi, Xi'an 710068, People's Republic of China; National Engineering Research Center for Miniaturized Detection System, Northwest University, Shaanxi, Xi'an 710069, People's Republic of China. Electronic address: rulinli@nwu.edu.cn.
2
Laboratory for Development, College of Life Sciences, Northwest University, Taibai west road 229#, Shaanxi, Xi'an 710068, People's Republic of China.
3
College of Pharmaceutical sciences, Chongqing Medical University, Chongqing 401331, People's Republic of China.
4
Department of Clinical Laboratory, Panyu central Hospital, Guang Zhou 511400, People's Republic of China.

Abstract

Advanced glycation end products (AGEs) plays an important role in diabetic embryopathy. AGE-mediated DNA damage could be a significant factor in the teratogenicity. The aim of the present study was to evaluate the association between the AGEs level and neural tube defects (NTDs) occurrence risk. Forty-eight mothers with NTD-affected pregnancies and 50 normal mothers were selected in this study. Blood were collected from the mothers and were assayed for serum AGEs, malondiadehyde (MDA) and hemoglobin A1c (HbA1c). Data were analyzed by logistic regression method. The study indicated that there were significant but modest lower prevalence for cases mothers on age, BMI and glucose levels compared with controls. NTD-affected mothers were significantly more likely to have higher AGEs levels (5.6±0.48 AU vs. 4.6±0.68 AU ρ<0.01) than controls. The AGEs levels were not correlated with MDA and HbA1c in NTDs mothers (r(2)=0.0006 p=0.8691 and r(2)=0.001 p=0.8172, respectively). The conclusion is that AGEs might be associated with NTDs occurrence.

KEYWORDS:

Advanced glycated end products; HbA1c; Malondiadehyde; Neural tube defect; Oxidative stress

PMID:
24345611
DOI:
10.1016/j.ijdevneu.2013.12.002
[Indexed for MEDLINE]

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