Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Eat Disord. 2014 Apr;47(3):329-34. doi: 10.1002/eat.22234. Epub 2013 Dec 16.

Lamotrigine use in patients with binge eating and purging, significant affect dysregulation, and poor impulse control.

Author information

1
Department of Psychiatry, University of California San Diego, San Diego, California.

Abstract

OBJECTIVE:

Some patients with symptoms of binge eating and purging are successfully treated with specific serotonin reuptake inhibitors (SSRIs), but others experience only partial or no benefit. Significant affect dysregulation and poor impulse control may be characteristics that limit responsiveness.

METHOD:

We report on the treatment of five patients with bulimia nervosa (BN), anorexia nervosa-binge/purge type (AN-B/P) or eating disorder not otherwise specified (EDNOS), using the anticonvulsant lamotrigine after inadequate response to SSRIs.

RESULTS:

Following addition of lamotrigine to an antidepressant in four cases, and switch from an antidepressant to lamotrigine in one case, patients experienced substantial improvement in mood reactivity and instability, impulsive drives and behaviors, and eating-disordered symptoms.

DISCUSSION:

These findings raise the possibility that lamotrigine, either as monotherapy or as an augmenting agent to antidepressants, may be useful in patients who binge eat and purge, and have significant affect dysregulation with poor impulse control.

KEYWORDS:

anorexia nervosa; anticonvulsants; binge eating; bulimia nervosa; dangerous behavior; eating disorder; impulsive behavior; lamotrigine; self-destructive behavior; self-injurious behavior

PMID:
24343841
DOI:
10.1002/eat.22234
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center