Format

Send to

Choose Destination
See comment in PubMed Commons below
Am J Clin Pathol. 2014 Jan;141(1):62-71. doi: 10.1309/AJCPMD5TJEFOOVBW.

Marrow assessment for hemophagocytic lymphohistiocytosis demonstrates poor correlation with disease probability.

Author information

1
Dept of Pathology, Yale School of Medicine, 310 Cedar St, LH 108, PO Box 208023, New Haven, CT 06520-8023; e-mail: mina.xu@yale.edu.

Abstract

OBJECTIVES:

To evaluate the amount of hemophagocytosis in 64 marrow core biopsy specimens and aspirates from 58 patients with clinical suspicion for secondary hemophagocytic lymphohistiocytosis (HLH) or reported findings of hemophagocytosis.

METHODS:

A review of medical records assigned patients to a low-risk (45 patients) or high-risk (13 patients) HLH group, and association with histologic findings was examined using the Fisher exact test.

RESULTS:

The amount of hemophagocytosis in aspirate or the core biopsy specimen did not correlate with disease probability (P = .17 and P = .63, respectively). Of the clinical/laboratory criteria assessed, the most significant correlations with HLH were highly elevated ferritin (P = .01), cytopenias (P = .02), and fever (P = .009).

CONCLUSIONS:

Our findings indicated that marrow histologic findings alone do not reliably predict the probability of HLH, and an isolated finding of hemophagocytosis, even when present in a high amount, lacks specificity for HLH.

KEYWORDS:

Bone marrow; Hemophagocytic; Hemophagocytosis; Lymphohistiocytosis

PMID:
24343738
DOI:
10.1309/AJCPMD5TJEFOOVBW
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center