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Cell Res. 2014 Feb;24(2):141-2. doi: 10.1038/cr.2013.165. Epub 2013 Dec 17.

Regenerative medicine: transdifferentiation in vivo.

Author information

1
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
2
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
3
1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China [2] Beijing Institute for Brain Disorders, Beijing 100069, China.
4
1] Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA [2] Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, Barcelona 08003, Spain.

Abstract

A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.

PMID:
24343579
PMCID:
PMC3915906
DOI:
10.1038/cr.2013.165
[Indexed for MEDLINE]
Free PMC Article
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