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Cell Res. 2014 Mar;24(3):307-30. doi: 10.1038/cr.2013.164. Epub 2013 Dec 17.

Cholecystokinin from the entorhinal cortex enables neural plasticity in the auditory cortex.

Author information

1
1] Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China [2] University of Chinese Academy of Sciences (CAS) and CAS-Hong Kong Joint Laboratory, Institute of Biophysics, Beijing 100101, China [3] University of Chinese Academy of Sciences (CAS) and CAS-Hong Kong Joint Laboratory, Institute of Biophysics, Beijing 100101, China.
2
1] Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong [2] Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.
3
1] Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China [2] Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
4
1] Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong [2] Division of Life Science, Hong Kong University of Science and Technology, Clearwater Bay, N.T., Hong Kong SAR, China.
5
1] Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [2] Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, Guangdong 510530, China.
6
1] Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, China [2] University of Chinese Academy of Sciences (CAS) and CAS-Hong Kong Joint Laboratory, Institute of Biophysics, Beijing 100101, China [3] University of Chinese Academy of Sciences (CAS) and CAS-Hong Kong Joint Laboratory, Institute of Biophysics, Beijing 100101, China [4] Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [5] Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou, Guangdong 510530, China.

Abstract

Patients with damage to the medial temporal lobe show deficits in forming new declarative memories but can still recall older memories, suggesting that the medial temporal lobe is necessary for encoding memories in the neocortex. Here, we found that cortical projection neurons in the perirhinal and entorhinal cortices were mostly immunopositive for cholecystokinin (CCK). Local infusion of CCK in the auditory cortex of anesthetized rats induced plastic changes that enabled cortical neurons to potentiate their responses or to start responding to an auditory stimulus that was paired with a tone that robustly triggered action potentials. CCK infusion also enabled auditory neurons to start responding to a light stimulus that was paired with a noise burst. In vivo intracellular recordings in the auditory cortex showed that synaptic strength was potentiated after two pairings of presynaptic and postsynaptic activity in the presence of CCK. Infusion of a CCKB antagonist in the auditory cortex prevented the formation of a visuo-auditory association in awake rats. Finally, activation of the entorhinal cortex potentiated neuronal responses in the auditory cortex, which was suppressed by infusion of a CCKB antagonist. Together, these findings suggest that the medial temporal lobe influences neocortical plasticity via CCK-positive cortical projection neurons in the entorhinal cortex.

PMID:
24343575
PMCID:
PMC3945883
DOI:
10.1038/cr.2013.164
[Indexed for MEDLINE]
Free PMC Article
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