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Hum Vaccin Immunother. 2014;10(3):536-43. Epub 2013 Dec 16.

Effectiveness of 2012-2013 influenza vaccine against influenza-like illness in general population: estimation in a French web-based cohort.

Author information

1
Institut National de la Santé et de la Recherche Médicale; Paris, France; Université Pierre et Marie Curie-Paris 6; Paris, France.
2
Institut National de la Santé et de la Recherche Médicale; Paris, France; Université Pierre et Marie Curie-Paris 6; Paris, France; Institute for Scientific Interchange; Torino, Italy.
3
Institut National de la Santé et de la Recherche Médicale; Paris, France; Université Pierre et Marie Curie-Paris 6; Paris, France; Université Versailles Saint Quentin en Yvelines; Versailles, France; Assistance Publique Hopitaux de Paris; Hopital Ambroise Paré; Boulogne Billancourt, France.
4
Institut National de la Santé et de la Recherche Médicale; Paris, France; Université de Corse; Laboratoire de Virologie; Corte, France.

Abstract

Most of the methods used for estimating the influenza vaccine effectiveness (IVE) target the individuals who have an influenza-like illness (ILI) rather than virologically-proven influenza and access the healthcare system. The objective of this study was to estimate the 2012-2013 IVE in general French population, using a cohort of volunteers registered on GrippeNet.fr, an online surveillance system for ILI. The IVE estimations were obtained through a logistic regression, and analyses were also performed by focusing on at-risk population of severe influenza, and by varying inclusion period and ILI definition. Overall, 1996 individuals were included in the analyses. The corrected IVE was estimated to 49% (20 to 67) for the overall population, and 32% (0 to 58) for the at-risk population. Three covariables appeared with a significant effect on the occurrence of at least one ILI during the epidemic: the age (P = 0.045), the presence of a child in the household (P<10(-3)), and the frequency of cold/flu (P<10(-3)). Comparable results were found at epidemic peak time in the hypothesis of real-time feed of data. In this study, we proposed a novel, follow-up, web-based method to reveal seasonal vaccine effectiveness, which enables analysis in a portion of the population that is not tracked by the health care system in most VE studies.

KEYWORDS:

GrippeNet; general population; influenza; vaccine; vaccine effectiveness

PMID:
24343049
PMCID:
PMC4130275
[Indexed for MEDLINE]
Free PMC Article

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