Format

Send to

Choose Destination
Nat Rev Genet. 2014 Feb;15(2):69-81. doi: 10.1038/nrg3623. Epub 2013 Dec 17.

Dynamic regulation of transcriptional states by chromatin and transcription factors.

Author information

1
Laboratory of Receptor Biology and Gene Expression, 41 Library Drive, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

The interaction of regulatory proteins with the complex nucleoprotein structures that are found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms that support these transitions are complex on many timescales, which range from milliseconds to minutes or hours. In this Review, we discuss emerging concepts regarding the function of regulatory elements in living cells. We also explore the involvement of these dynamic and stochastic processes in the evolution of fluctuating transcriptional activity states that are now commonly reported in eukaryotic systems.

PMID:
24342920
PMCID:
PMC6322398
DOI:
10.1038/nrg3623
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center