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Mech Ageing Dev. 2014 Mar-Apr;136-137:3-13. doi: 10.1016/j.mad.2013.12.001. Epub 2013 Dec 14.

Combating inflammaging through a Mediterranean whole diet approach: the NU-AGE project's conceptual framework and design.

Author information

1
University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Via San Giacomo 12, 40126 Bologna, Italy. Electronic address: aurelia.santoro@unibo.it.
2
C.I.G. Interdepartmental Centre "L. Galvani", University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.
3
University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Via San Giacomo 12, 40126 Bologna, Italy.
4
Wageningen University, Department of Human Nutrition, Wageningen, The Netherlands.
5
WULS-SGGW, Division of Human Nutrition, Warsaw, Poland.
6
INRA-Clermont Université, Centre de Recherche en Nutrition Humaine d'Auvergne, Clermont-Ferrand, France.
7
CHU Clermont-Ferrand, Unité d'Exploration en Nutrition, Clermont-Ferrand, France.
8
Norwich Medical School, University of East Anglia, Norwich, UK.
9
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
10
University of Bologna, Department of Experimental, Diagnostic and Specialty Medicine, Via San Giacomo 12, 40126 Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", University of Bologna, Via San Giacomo 12, 40126 Bologna, Italy.

Abstract

The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

KEYWORDS:

Ageing; Elderly-tailored foods; Gut microbiota; Inflammaging; Mediterranean diet

PMID:
24342354
DOI:
10.1016/j.mad.2013.12.001
[Indexed for MEDLINE]

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