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Addict Behav. 2014 Mar;39(3):652-9. doi: 10.1016/j.addbeh.2013.11.020. Epub 2013 Dec 1.

Heroin and amphetamine users display opposite relationships between trait and neurobehavioral dimensions of impulsivity.

Author information

1
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, United States. Electronic address: jvassileva@psych.uic.edu.
2
Kessler Foundation Research Center, West Orange, NJ 07052, United States.
3
Virginia Commonwealth University, Richmond, VA 23284, United States.
4
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, United States.
5
Bulgarian Addictions Institute, Sofia 1336, Bulgaria.
6
Department of Psychiatry, Rush University Medical Center, Chicago, IL 60612, United States.
7
Department of Psychology, Florida International University, Miami, FL 33199, United States.

Abstract

The multidimensional construct of impulsivity is implicated in all phases of the addiction cycle. Substance dependent individuals (SDIs) demonstrate elevated impulsivity on both trait and laboratory tests of neurobehavioral impulsivity; however our understanding of the relationship between these different aspects of impulsivity in users of different classes of drugs remains rudimentary. The goal of this study was to assess for commonalities and differences in the relationships between trait and neurobehavioral impulsivity in heroin and amphetamine addicts. Participants included 58 amphetamine dependent (ADIs) and 74 heroin dependent individuals (HDIs) in protracted abstinence. We conducted Principal Component Analyses (PCA) on two self-report trait and six neurobehavioral measures of impulsivity, which resulted in two trait impulsivity (action, planning) and four neurobehavioral impulsivity composites (discriminability, response inhibition efficiency, decision-making efficiency, quality of decision-making). Multiple regression analyses were used to determine whether neurobehavioral impulsivity is predicted by trait impulsivity and drug type. The analyses revealed a significant interaction between drug type and trait action impulsivity on response inhibition efficiency, which showed opposite relationships for ADIs and HDIs. Specifically, increased trait action impulsivity was associated with worse response inhibition efficiency in ADIs, but with better efficiency in HDIs. These results challenge the unitary account of drug addiction and contribute to a growing body of literature that reveals important behavioral, cognitive, and neurobiological differences between users of different classes of drugs.

KEYWORDS:

Amphetamine; Drug addiction; Heroin; Impulsivity

PMID:
24342174
PMCID:
PMC3929020
DOI:
10.1016/j.addbeh.2013.11.020
[Indexed for MEDLINE]
Free PMC Article
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