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Org Lett. 2014 Jan 17;16(2):456-9. doi: 10.1021/ol4033418. Epub 2013 Dec 16.

Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

Author information

1
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536, United States.

Abstract

The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to display moderate antifungal activity.

PMID:
24341358
PMCID:
PMC3964319
DOI:
10.1021/ol4033418
[Indexed for MEDLINE]
Free PMC Article

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