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Chem Commun (Camb). 2014 Feb 7;50(10):1234-7. doi: 10.1039/c3cc48088g.

Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.

Author information

1
Department of Physics and Department of Mechanical & Materials Engineering, Portland State University, P.O. Box 751, Portland, OR 97207-0751, USA. jiaoj@pdx.edu.

Abstract

To create an effective well-ordered delivery platform still remains a challenge. Herein we fabricate vertically aligned alumina nanowire arrays via atomic layer deposition templated by carbon nanotubes. Using these arrays, a caspase-3/7 inhibitor was delivered into DC 2.4 cells and blocked apoptosis, as confirmed by fluorescence microscopy.

PMID:
24336780
PMCID:
PMC3929101
DOI:
10.1039/c3cc48088g
[Indexed for MEDLINE]
Free PMC Article
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