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Nat Rev Microbiol. 2014 Jan;12(1):35-48. doi: 10.1038/nrmicro3155.

Ribosome-targeting antibiotics and mechanisms of bacterial resistance.

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Gene Center and Department for Biochemistry, Feodor-Lynenstr. 25, University of Munich, 81377 Munich, Germany.


The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.

[Indexed for MEDLINE]

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