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Nat Rev Immunol. 2014 Jan;14(1):51-9. doi: 10.1038/nri3561. Epub 2013 Dec 13.

Concepts of tissue injury and cell death in inflammation: a historical perspective.

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Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel.
Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-701, South Korea.

Erratum in

  • Nat Rev Immunol. 2014 Feb;14(2):131.


Emerging evidence indicates that the molecular mechanisms of cell death have regulatory roles in inflammation and that the molecular changes that are associated with different forms of cell death affect the course of inflammation in different ways. In this Timeline article, we discuss how our understanding of the mechanisms and functional roles of tissue injury and cell death in inflammation has evolved on the basis of almost two centuries of study. We describe how such ideas have led to our current models of cell death and inflammation, and we highlight the remaining gaps in our knowledge of the subject.

[Indexed for MEDLINE]

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