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Nature. 1987 Jan 22-28;325(6102):321-6.

The beta gamma subunits of GTP-binding proteins activate the muscarinic K+ channel in heart.

Abstract

Subunits of guanine nucleotide regulatory proteins purified from bovine cerebral cortex were used to perfuse the intracellular surface of excised patches of chick embryonic atrial cells. Single-channel current measurements unexpectedly indicate that the beta gamma, and not the alpha subunits, are responsible for activating the muscarinic-gated potassium channel.

PMID:
2433589
DOI:
10.1038/325321a0
[Indexed for MEDLINE]

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