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Brief Funct Genomics. 2014 Mar;13(2):95-105. doi: 10.1093/bfgp/elt049. Epub 2013 Dec 12.

Transcriptome dynamics and diversity in the early zebrafish embryo.

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BasAM, Norwegian School of Veterinary Science, Dep., 0033 Oslo, Norway.


Recent years advances in high-throughput sequencing have improved our understanding of how transcripts regulate early vertebrate development. Here, we review the transcriptome dynamics and diversity during early stages of zebrafish embryogenesis. Transcriptome dynamics is characterized by different patterns of mRNA degradation, activation of dormant transcripts and onset of transcription. Several studies have shown a striking diversity of both coding and non-coding transcripts. However, in the aftermath of this immense increase in data, functional studies of both protein-coding and non-coding transcripts are lagging behind. We anticipate that the forthcoming years will see studies relying on different high-throughput sequencing technologies and genomic tools developed for zebrafish embryos to further pin down yet un-annotated transcript-function relationships.


MBT; RNA-seq; ZGA; early development; transcriptomics; zebrafish

[Indexed for MEDLINE]

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