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Genes Immun. 2014 Mar;15(2):82-7. doi: 10.1038/gene.2013.65. Epub 2014 Jan 16.

Idd13 is involved in determining immunoregulatory DN T-cell number in NOD mice.

Author information

1] Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada [2] Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
Autoimmune Genetics Laboratory, Department of Microbiology and Immunology, VIB and University of Leuven, Leuven, Belgium.
Research Center, Immunology-Oncology Section, Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada.
Division of Biomedical Sciences, University of Canberra, Bruce, Canberra, Australia.

Erratum in

  • Genes Immun. 2014 Apr;15(4):263.


Immunoregulatory T cells have been identified as key modulators of peripheral tolerance and participate in preventing autoimmune diseases. CD4(-)CD8(-) (double negative, DN) T cells compose one of these immunoregulatory T-cell subsets, where the injection of DN T cells confers protection from autoimmune diabetes progression. Interestingly, genetic loci defining the function and number of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) coincide with at least some autoimmune disease susceptibility loci. Herein, we investigate the impact of major insulin-dependent diabetes (Idd) loci in defining the number of DN T cells. We demonstrate that although Idd3, Idd5 and Idd9 loci do not regulate DN T-cell number, NOD mice congenic for diabetes resistance alleles at the Idd13 locus show a partial restoration in DN T-cell number. Moreover, competitive and non-competitive bone marrow chimera experiments reveal that DN T-cell number is defined by a bone marrow-intrinsic, but DN T-cell-extrinsic, factor. This suggests that non-autonomous candidate genes define DN T-cell number in secondary lymphoid organs. Together, our results show that the regulation of DN T-cell number in NOD mice is at least partially conferred by alleles at the Idd13 locus.

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