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J R Soc Interface. 2013 Dec 11;11(91):20131023. doi: 10.1098/rsif.2013.1023. Print 2014 Feb 6.

An automatic service for the personalization of ventricular cardiac meshes.

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Department of Biomedical Engineering, King's College of London, St Thomas' Hospital, , London SE1 7EH, UK.


Computational cardiac physiology has great potential to improve the management of cardiovascular diseases. One of the main bottlenecks in this field is the customization of the computational model to the anatomical and physiological status of the patient. We present a fully automatic service for the geometrical personalization of cardiac ventricular meshes with high-order interpolation from segmented images. The method is versatile (able to work with different species and disease conditions) and robust (fully automatic results fulfilling accuracy and quality requirements in 87% of 255 cases). Results also illustrate the capability to minimize the impact of segmentation errors, to overcome the sparse resolution of dynamic studies and to remove the sometimes unnecessary anatomical detail of papillary and trabecular structures. The smooth meshes produced can be used to simulate cardiac function, and in particular mechanics, or can be used as diagnostic descriptors of anatomical shape by cardiologists. This fully automatic service is deployed in a cloud infrastructure, and has been made available and accessible to the scientific community.


cardiac modelling; computational mesh; computational physiology

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