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AJNR Am J Neuroradiol. 2014 May;35(5):1022-8. doi: 10.3174/ajnr.A3799. Epub 2013 Dec 12.

Quantitative cerebral perfusion imaging in children and young adults with Moyamoya disease: comparison of arterial spin-labeling-MRI and H(2)[(15)O]-PET.

Author information

1
From the Departments of Diagnostic Imaging (R. Goetti, R. Guggenberger, I.S.)Diagnostic and Interventional Radiology (R. Goetti, F.P.K., R. Guggenberger) robertpaul.goetti@usz.ch.
2
Nuclear Medicine (G.W., F.P.K., A.B.).
3
Diagnostic and Interventional Radiology (R. Goetti, F.P.K., R. Guggenberger)Nuclear Medicine (G.W., F.P.K., A.B.).
4
From the Departments of Diagnostic Imaging (R. Goetti, R. Guggenberger, I.S.)Diagnostic and Interventional Radiology (R. Goetti, F.P.K., R. Guggenberger).
5
Center for MR Research (R.O.).
6
the Moyamoya Center, Division of Neurosurgery, Department of Surgery (N.K.), University Children's Hospital Zurich, Zurich, Switzerland.
7
From the Departments of Diagnostic Imaging (R. Goetti, R. Guggenberger, I.S.).

Abstract

BACKGROUND AND PURPOSE:

Cerebral perfusion assessment is important in the preoperative evaluation and postoperative follow-up of patients with Moyamoya disease. The objective of this study was to evaluate the correlation of quantitative CBF measurements performed with arterial spin-labeling-MR imaging and H2[(15)O]-PET in children and young adults with Moyamoya disease.

MATERIALS AND METHODS:

Thirteen children and young adults (8 female patients; age, 9.7 ± 7.1 years; range, 1-23 years) with Moyamoya disease underwent cerebral perfusion imaging with H2[(15)O]-PET (Discovery STE PET/CT, 3D Fourier rebinning filtered back-projection, 128 × 128 × 47 matrix, 2.34 × 2.34 × 3.27 mm(3) voxel spacing) and arterial spin-labeling (3T scanner, 3D pulsed continuous arterial spin-labeling sequence, 32 axial sections, TR = 5.5 seconds, TE = 25 ms, FOV = 24 cm, 128 × 128 matrix, 1.875 × 1.875 × 5 mm(3) voxel spacing) within less than 2 weeks of each other. Perfusion of left and right anterior cerebral artery, MCA, and posterior cerebral artery territories was qualitatively assessed for arterial spin-labeling-MR imaging and H2[(15)O]-PET by 2 independent readers by use of a 3-point-Likert scale. Quantitative correlation of relative CBF with cerebellar normalization between arterial spin-labeling-MR imaging and H2[(15)O]-PET was evaluated in a volume-based approach for each vascular territory after 3D image coregistration.

RESULTS:

Interreader agreement was good (κ = 0.67-0.69), and strong and significant correlations were found between arterial spin-labeling-MR imaging and H2[(15)O]-PET for both qualitative perfusion scoring (ρ = 0.77; P < .001) and quantitative perfusion assessment of relative CBF with cerebellar normalization (r = 0.67, P < .001).

CONCLUSIONS:

In children and young adults with Moyamoya disease, quantitative evaluation of CBF is possible with the use of arterial spin-labeling-MR imaging without ionizing radiation or contrast injection with a good correlation to H2[(15)O]-PET after cerebellar normalization.

PMID:
24335546
DOI:
10.3174/ajnr.A3799
[Indexed for MEDLINE]
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