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Virulence. 2014 Jan 1;5(1):190-9. doi: 10.4161/viru.27409. Epub 2013 Dec 11.

Severe sepsis and septic shock: management and performance improvement.

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Division of Critical Care Medicine; Department of Medicine; Cooper University Hospital; Camden, NJ USA.


Morbidity and mortality from sepsis remains unacceptably high. Large variability in clinical practice, plus the increasing awareness that certain processes of care associated with improved critical care outcomes, has led to the development of clinical practice guidelines in a variety of areas related to infection and sepsis. The Surviving Sepsis Guidelines for Management of Severe Sepsis and Septic Shock were first published in 2004, revised in 2008, and recently revised again and published in 2013. The first part of this manuscript is a summary of the 2013 guidelines with some editorial comment. The second part of the manuscript characterizes hospital based sepsis performance improvement programs and highlights the sepsis bundles from the Surviving Sepsis Campaign as a key component of such a program.


guidelines; performance improvement; resuscitation; sepsis bundles; severe sepsis

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