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Phlebology. 2015 Mar;30(2):119-26. doi: 10.1177/0268355513515650. Epub 2013 Dec 13.

Transcranial brain photoplethysmography to study the venules of cerebral cortex in patients with multiple sclerosis.

Author information

1
Department of Neurology, S. Pio Hospital, Vasto (CH), Italy stefano.viola@email.it.
2
Emergency Medical Service, S.C. De Lellis Hospital, Atessa (CH), Italy.
3
Department of Neurology, S. Pio Hospital, Vasto (CH), Italy.

Abstract

OBJECTIVE:

To evaluate the utility of a transcranial brain photoplethysmography parameter as a potential marker for patients with multiple sclerosis.

METHODS:

We investigated 38 patients affected by multiple sclerosis, according to the revised McDonald criteria (12 males and 26 females, mean age 41.1 ± 8.5 years, Expanded Disability Status Scale mean value 2.6 ± 2.1) and compared them with 20 age- and sex-matched healthy controls. By means of transcranial brain photoplethysmography, a safe and non-invasive technology, we measured the increase in cerebral blood volume during compression for 10 s of the internal jugular veins of both sides in sitting position.

RESULTS:

The cerebral blood volume increase was significantly smaller in the multiple sclerosis patients (left frontal cortex: -58%, p < 0.0001; right frontal cortex: -59%, p < 0.0001) compared with the controls.

CONCLUSIONS:

Our study reveals that a minor increase in cerebral blood volume on the frontal cortex of both sides in sitting position is associated with a diagnosis of multiple sclerosis and might be a new marker.

KEYWORDS:

CCSVI; Queckenstedt’s manoeuvre; Transcranial brain photoplethysmography; cerebral venular disorder; multiple sclerosis

PMID:
24335101
DOI:
10.1177/0268355513515650
[Indexed for MEDLINE]
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