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Mol Biochem Parasitol. 2013 Nov-Dec;192(1-2):1-9. doi: 10.1016/j.molbiopara.2013.11.003. Epub 2013 Dec 11.

Chemical biology approaches for the study of apicomplexan parasites.

Author information

1
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: machild@stanford.edu.

Abstract

Chemical biology and the techniques the field encompasses provide scientists with the means to address biological questions in ever-evolving and technically sophisticated ways. They facilitate the dissection of molecular mechanisms of cell phenomena on timescales not achievable by other means. Libraries of small molecules, bioorthogonal chemistries and technical advances in mass-spectrometry techniques enable the modern chemical biologist to tackle even the most difficult of biological questions. It is because of their broad applicability that these approaches are well suited to systems less tractable to more classical genetic methods. As such, the parasite community has embraced them with great success. Some of these successes and the continuing evolution of chemical biology applied to apicomplexans will be discussed.

KEYWORDS:

Apicomplexan; Bioorthogonal; Chemical biology; Small molecule

PMID:
24333788
PMCID:
PMC3945044
DOI:
10.1016/j.molbiopara.2013.11.003
[Indexed for MEDLINE]
Free PMC Article

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