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Cancer Lett. 2014 Mar 28;344(2):174-9. doi: 10.1016/j.canlet.2013.11.019. Epub 2013 Dec 11.

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents.

Author information

1
Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China; Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
2
Department of General Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
3
Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
4
Department of Gastrointestinal Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China. Electronic address: hz166cn@163.com.
5
Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China. Electronic address: drhechao@yahoo.com.cn.
6
Department of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China; Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China. Electronic address: hzzju@zju.edu.cn.

Abstract

The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit extracellular signals to regulate cell growth, proliferation, differentiation, migration, apoptosis and so on. Apoptosis as well as macroautophagy (hereafter referred to as autophagy) can be induced by extracellular stimuli such the treatment of chemotherapeutic agents, resulting in different cell response to these drugs. However, the molecular mechanisms mediating these two cellular processes remain largely unknown. Recently, several studies provide new insights into p38 and JNK MAPK pathways function in the control of the balance of autophagy and apoptosis in response to genotoxic stress. Our increased understanding of the role of p38 and JNK MAPK pathways in regulating the balance of autophagy and apoptosis will hopefully provide prospective strategies for cancer therapy.

KEYWORDS:

Apoptosis; Autophagy; Chemoresistance; JNK; P38

PMID:
24333738
DOI:
10.1016/j.canlet.2013.11.019
[Indexed for MEDLINE]

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