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Exp Cell Res. 2014 Feb 1;321(1):32-9. doi: 10.1016/j.yexcr.2013.12.004. Epub 2013 Dec 11.

Lineage specification in the early mouse embryo.

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1
Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Karolinska Universitetssjukhuset, K 57 CLINTEC, 141 86 Stockholm, Sweden. Electronic address: Fredrik.Lanner@ki.se.

Abstract

Before the mammalian embryo is ready to implant in the uterine wall, the single cell zygote must divide and differentiate into three distinct tissues; trophectoderm (prospective placenta), primitive endoderm (prospective yolk sac), and pluripotent epiblast cells which will form the embryo proper. In this review I will discuss our current understanding of how positional information, cell polarization, signaling pathways, and transcription factor networks converge to drive and regulate the progressive segregation of the first three cell types in the mouse embryo.

KEYWORDS:

Lineage specification; Mouse development; Preimplantation development

PMID:
24333597
DOI:
10.1016/j.yexcr.2013.12.004
[Indexed for MEDLINE]
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