Send to

Choose Destination
See comment in PubMed Commons below
Neurosci Lett. 2014 Jan 24;559:111-6. doi: 10.1016/j.neulet.2013.11.052. Epub 2013 Dec 9.

Amelioration of improper differentiation of somatostatin-positive interneurons by triiodothyronine in a growth-retarded hypothyroid mouse strain.

Author information

  • 1Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan. Electronic address:
  • 2Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
  • 3Department of Stomatology and Oral Surgery, Graduate School of Medicine, Gunma University, Maebashi, Japan.
  • 4Health Effects Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan.
  • 5Laboratory of Information Biology, Graduate School of Information Sciences, Tohoku University, Sendai, Japan.


Thyroid hormone (TH) plays an important role in brain development, and TH deficiency during pregnancy or early postnatal periods leads to neurological disorders such as cretinism. Hypothyroidism reduces the number of parvalbumin (PV)-positive interneurons in the neocortex and hippocampus. Here we used a mouse strain (growth-retarded; grt) that shows growth retardation and hypothyroidism to examine whether somatostatin (Sst)-positive interneurons that are generated from the same pool of neural progenitor cells as PV-positive cells are also altered by TH deficiency. The number of PV-positive interneurons was significantly decreased in the neocortex and hippocampus of grt mice as compared with normal control mice. In contrast to the decrease in the number of PV neurons, the number of Sst-positive interneurons in grt mice was increased in the stratum oriens of the hippocampus and the hilus of the dentate gyrus, although their number was unchanged in the neocortex. These changes were reversed by triiodothyronine administration from postnatal day (PD) 0 to 20. TH supplementation that was initiated after PD21 did not, however, affect the number of PV- or Sst-positive cells. These results suggest that during the first three postnatal weeks, TH may be critical for the generation of subpopulations of interneurons.


Hippocampus; Hypothyroid; Neocortex; Parvalbumin; Somatostatin; Thyroid hormone

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center