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Blood Transfus. 2014 Jan;12(1):56-60. doi: 10.2450/2013.0013-13. Epub 2013 Nov 15.

Prevalence, specificity and risk of red blood cell alloantibodies among hospitalised Hubei Han Chinese patients.

Xu P1, Li Y2, Yu H1.

Author information

1
Department of Blood Transfusion, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
2
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.

Abstract

BACKGROUND:

The prevalence, specificity and risk of red blood cell alloantibodies vary widely among different geographic areas, races, and diseases and according to different methods of study, but no data are available on the Chinese Han population, who were investigated in the present study.

MATERIALS AND METHODS:

Antibody screening was conducted among 42,517 hospitalised Hubei Han Chinese individuals using column agglutination technology. Samples that were positive in antibody screening were subjected to antibody identification by the tube test. Clinical data, including gender, age, race, transfusion history and records of alloantibody detection, transfusion reactions or haemolytic disease of the newborn, were collected to analyse the prevalence and specificity of alloantibodies and complications associated with them.

RESULTS:

A total of 212 patients with alloantibodies were identified among 42,517 patients, yielding a prevalence of 0.50% in this study. Significantly different prevalence rates were observed according to age and sex. The most frequently identified alloantibodies were anti-E (87/212, 41.0%), anti-D (45/212, 21.2%), anti-M (41/212, 19.3%) and a combination of anti-E and anti-c (13/212, 6.1%). Haemolytic disease was observed in 13 infants with anti-D, three infants with anti-E and one infant with anti-Fy(a) alloantibodies. Delayed haemolytic transfusion reactions occurred in four patients with alloantibodies.

DISCUSSION:

In hospitalised Hubei Han Chinese individuals, the overall prevalence of alloantibodies was 0.50%, with anti-E, anti-D and anti-M being the most frequently identified alloantibodies. These results indicate that anti-D and anti-E alloantibodies were major risk factors for haemolytic disease of the newborn or delayed haemolytic transfusion reactions in this study population.

PMID:
24333071
PMCID:
PMC3926729
DOI:
10.2450/2013.0013-13
[Indexed for MEDLINE]
Free PMC Article

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