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Clin Imaging. 2014 Mar-Apr;38(2):208-11. doi: 10.1016/j.clinimag.2013.10.007. Epub 2013 Nov 7.

⁶⁸Ga-DOTATOC PET-CT in the localization of source of ectopic ACTH in patients with ectopic ACTH-dependent Cushing's syndrome.

Author information

1
Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
2
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
3
Department of Endocrinology, All India Institute of Medical Sciences, New Delhi, India.
4
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: rkphulia@yahoo.com.

Abstract

Localization of the source of adrenocorticotrophic hormone (ACTH) in ectopic ACTH-induced Cushing's syndrome is of paramount importance as definitive management mainly involves surgical resection of tumor. Many of these are occult, not identified by conventional structural imaging. Accurate localization and assessment of their functional status has become feasible with the use positron emission tomography-computerized tomography using (68)Ga-DOTATOC (1,4,7,10-tetraazacy-clododecane-NI,NII,NIII,NIIII-tetraacetic acid(D)-Phe1-thy3-octreotide), aiding in proper planning for their definitive management.

KEYWORDS:

(68)Ga-DOTATOC; Ectopic ACTH-dependent Cushing's syndrome; Neuroendocrine tumors; PET-CT

PMID:
24332975
DOI:
10.1016/j.clinimag.2013.10.007
[Indexed for MEDLINE]
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