Format

Send to

Choose Destination
See comment in PubMed Commons below
J Diabetes Complications. 2014 Mar-Apr;28(2):214-8. doi: 10.1016/j.jdiacomp.2013.09.009. Epub 2013 Oct 4.

Coronary heart disease risk equivalence in diabetes and arterial diseases characterized by endothelial function and endothelial progenitor cell.

Author information

1
Department of Endocrinology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
2
Department of Orthopedics, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
3
Department of Endocrinology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China. Electronic address: yunfeiliao2012@hotmail.com.
4
Department of Ultrasound Diagnosis, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Abstract

AIMS:

Peripheral Arterial Disease (PAD), Carotid Artery Disease (CAD), and Type 2 Diabetes Mellitus (DM) were considered as "Coronary Heart Disease (CHD) risk equivalents". Vascular endothelial dysfunction was recognized as an early event in the development of atherosclerosis. Involved in neovasculogenesis and maintenance of vascular homeostasis, endothelial progenitor cell (EPC) has been considered as a biological marker of cardiovascular disease. The purpose of this study was to assess the CHD risk equivalents concept by investigating the endothelial function and circulating EPC number in patients with CHD, PAD, CAD and T2DM.

METHODS:

There were four groups in the study: CHD (n = 19), AD [PAD and CAD (n = 17)], DM (n = 21) and healthy controls (HC, n = 20). PAD and CAD were assessed by ultrasonography. Coronal artery angiography was used to identify CHD. The diagnosis of T2DM was based on oral glucose tolerance test and medical history. Vascular endothelial function was assessed by flow-mediated brachial artery dilatation (FMD). Circulating EPC was quantified by flow cytometry.

RESULTS:

The circulating EPC numbers in four groups were CHD, 973 ± 96; AD, 1048 ± 97; T2DM, 1210 ± 125; HC, 1649 ± 112 cells/ml. There were no significant differences in circulating EPC numbers between CHD and AD groups (P > 0.05). Compared with CHD or AD group, T2DM group was associated with a slight increase in circulating EPC numbers (P < 0.05). The results of FMD were almost similar to the circulating EPC numbers(CHD, 4.06 ± 0.54; AD, 3.90 ± 0.48; DM, 3.85 ± 0.57; HC, 5.52 ± 0.67%)except that there was no significant difference among the CHD, AD and T2DM groups (P > 0.05). Age, glycosylated hemoglobin, low density lipoprotein cholesterol, systolic blood pressure, body mass index (BMI) and medical history were the independent risk factors of circulating EPC number in all the patients (P < 0.05). Age, total cholesterol, BMI and medical history were the independent risk factors of FMD in all of the patients (P<0.05).

CONCLUSIONS:

The results of this study supported the equivalents hypothesis and revealed that "CHD risk equivalents" were characterized by the consistent physiological changes of blood vessels in angiogenesis, repairing ability and endothelial function.

KEYWORDS:

Carotid artery disease; Coronary heart disease; Endothelial function; Endothelial progenitor cell; Peripheral arterial disease; Risk equivalents; Type 2 diabetes

PMID:
24332936
DOI:
10.1016/j.jdiacomp.2013.09.009
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center