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Arch Gerontol Geriatr. 2014 May-Jun;58(3):415-9. doi: 10.1016/j.archger.2013.11.005. Epub 2013 Nov 22.

Do Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) progress differently?

Author information

1
Department of Neurology, Yong-In Hyoja Geriatric Hospital, 33 Sangha-dong, Giheung-gu, Yongin 446-769, Republic of Korea.
2
Department of Neurology, Konyang University College of Medicine, 685 Gawuwon-dong, Seo-gu, Daejeon 302-718, Republic of Korea.
3
Department of Neurology, Catholic University of Korea, The College of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea.
4
Department of Neurology, Konkuk University School of Medicine, Hwayang-dong, Gwangjin-gu, Seoul 143-729, Republic of Korea.
5
Department of Neurology, Gachon University Gil Medical Center, Guwol 1-dong, Namdong-gu, Incheon 405-760, Republic of Korea.
6
Department of Neurology, Inha University School of Medicine, Sinheung-dong 3 ga, Jung-gu, Incheon 400-711, Republic of Korea.
7
Department of Neurology, Myongji Hospital, Kwandong University College of Medicine, Hwajeong 1-dong, Deogyang-gu, Goyang 412-826, Republic of Korea.
8
Department of Neurology, Catholic University of Korea, The College of Medicine, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Republic of Korea. Electronic address: neuroman@catholic.ac.kr.

Abstract

Our study aimed to compare cognitive status and declines in AD with/without small vessel disease (SVD) and SIVD at baseline and 1-year follow-up. Patients with Alzheimer's disease without small vessel disease (AD(-)SVD) (n=148), Alzheimer's disease with small vessel disease (AD(+)SVD) (n=94) and SIVD (n=60) were recruited from database of multiple centers in Korea. Basic demographics and detailed neuropsychological results were compared. AD, regardless of SVD, showed worse memory and better executive function than SIVD at baseline. Mini-Mental State Examination scores and visual memory function declined more in AD than those in SIVD whereas Barthel Activities of Daily Living (B-ADL) scores declined more in SIVD. AD showed different patterns of cognitive impairment compared with SIVD. After 1 year, AD showed more rapid cognitive decline in some domains. Further investigations with longer follow-up duration may be needed to confirm the cumulative effects of SVD in AD and different patterns of decline between AD and SIVD.

KEYWORDS:

AD; Cognitive neuropsychology; Disease progression; SIVD; SVD

PMID:
24332770
DOI:
10.1016/j.archger.2013.11.005
[Indexed for MEDLINE]

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