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Trends Immunol. 2014 Feb;35(2):69-78. doi: 10.1016/j.it.2013.11.003. Epub 2013 Dec 11.

Pathogenic memory type Th2 cells in allergic inflammation.

Author information

1
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
2
Department of Advanced Allergology of the Airway, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
3
Department of Immunology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan; Japan Science and Technology Agency (JST), CREST, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. Electronic address: tnakayama@faculty.chiba-u.jp.

Abstract

Immunological memory is a hallmark of adaptive immunity. Memory CD4 T helper (Th) cells are central to acquired immunity, and vaccines for infectious diseases are developed based on this concept. However, memory Th cells also play a critical role in the pathogenesis of various chronic inflammatory diseases, including asthma. We refer to these populations as 'pathogenic memory Th cells.' Here, we review recent developments highlighting the functions and characteristics of several pathogenic memory type Th2 cell subsets in allergic inflammation. Also discussed are the similarities and differences between pathogenic memory Th2 cells and recently identified type 2 innate lymphoid cells (ILC2), focusing on cytokine production and phenotypic profiles.

KEYWORDS:

IL-5; ILC2; asthma; memory Th2 diversity; pathogenic T cells

PMID:
24332592
DOI:
10.1016/j.it.2013.11.003
[Indexed for MEDLINE]

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