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Curr Biol. 2014 Jan 6;24(1):63-69. doi: 10.1016/j.cub.2013.11.011. Epub 2013 Dec 12.

Optogenetic and electrical microstimulation systematically bias visuospatial choice in primates.

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Department of Neuroscience, Brown University, Providence, RI 02912, USA.
Department of Neuroscience, Brown University, Providence, RI 02912, USA. Electronic address:


Optogenetics is a recently developed method in which neurons are genetically modified to express membrane proteins sensitive to light, enabling precisely targeted control of neural activity [1-3]. The temporal and spatial precision afforded by neural stimulation by light holds promise as a powerful alternative to current methods of neural control, which rely predominantly on electrical and pharmacological methods, in both research and clinical settings [4, 5]. Although the optogenetic approach has been widely used in rodent and other small animal models to study neural circuitry [6-8], its functional application in primate models has proven more difficult. In contrast to the relatively large literature on the effects of cortical electrical microstimulation in perceptual and decision-making tasks [9-13], previous studies of optogenetic stimulation in primates have not demonstrated its utility in similar paradigms [14-18]. In this study, we directly compare the effects of optogenetic activation and electrical microstimulation in the lateral intraparietal area during a visuospatial discrimination task. We observed significant and predictable biases in visual attention in response to both forms of stimulation that are consistent with the experimental modulation of a visual salience map. Our results demonstrate the power of optogenetics as a viable alternative to electrical microstimulation for the precise dissection of the cortical pathways of high-level processes in the primate brain.

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