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Can J Psychiatry. 2013 Dec;58(12):679-86.

Functional impairment in patients with major depressive disorder and comorbid anxiety disorder.

Author information

1
Professor, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), University of Balearic Islands, Palma de Mallorca, Spain; Senior Researcher, Red de Actividades Preventivas y Promoción de la Salud en Atención Primaria (RediAPP), Palma de Mallorca, Spain.
2
Manager, Almirall Medical Department, Barcelona, Spain.
3
Associate Professor, Department of Psychiatry, Miguel Servet Hospital, University of Zaragoza, Zaragoza, Spain.
4
Doctoral Student, Institut Universitari d'Investigació en Ciències de la Salut (IUNICS), University of Balearic Islands, Palma de Mallorca, Spain.

Abstract

in English, French

OBJECTIVE:

To analyze the potential for different aspects of anxiety to modify the effect of impaired functioning in major depressive disorder (MDD).

METHODS:

Participants (n = 1226) were psychiatric outpatients with MDD. A cross-sectional, multicentre, nationwide study was designed. The 12-item version of the World Health Organization Disability Assessment Schedule II was used to assess functional limitation. Anxiety was measured using the Hamilton Anxiety Rating Scale and the State-Trait Anxiety Inventory (STAI). Depression severity was measured using the Quick Inventory of Depressive Symptomatology.

RESULTS:

About 43.1% of patients had a comorbid MDD and anxiety disorder. Poorer functioning correlated significantly with severity of depression (Pearson r = 0.78, P = 0.001), severity of anxiety (r = 0.65, P = 0.001), and higher anxiety trait scores (r = 0.40, P = 0.001), but not significantly with STAI-State scores (r = 0.03, P = 0.26). The overall regression model was significant and explained 66% of the functioning variability in patients with MDD, mostly attributable to depression severity. Results indicate that anxiety has a moderate impact on functioning impairment in patients with MDD.

CONCLUSIONS:

Our findings suggest that MDD and anxiety severity appear to be associated significantly with impaired functioning in patients with MDD but explains only a moderate proportion of variance.

KEYWORDS:

anxiety; comorbidity; depression; disability; functional impairment

PMID:
24331287
DOI:
10.1177/070674371305801205
[Indexed for MEDLINE]

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