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Br J Pharmacol. 2014 Apr;171(8):1890-906. doi: 10.1111/bph.12516.

Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular disease.

Author information

1
The Hatter Cardiovascular Institute, Institute of Cardiovascular Science, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospital & Medical School, London, UK.

Abstract

Mitochondria are no longer considered to be solely the static powerhouses of the cell. While they are undoubtedly essential to sustaining life and meeting the energy requirements of the cell through oxidative phosphorylation, they are now regarded as highly dynamic organelles with multiple functions, playing key roles in cell survival and death. In this review, we discuss the emerging role of mitochondrial fusion and fission proteins, as novel therapeutic targets for treating a wide range of cardiovascular diseases.

KEYWORDS:

Drp1; MFN1; MFN2; OPA1; mitochondrial dynamics; mitochondrial fission; mitochondrial fusion; mitochondrial morphology

PMID:
24328763
PMCID:
PMC3976611
DOI:
10.1111/bph.12516
[Indexed for MEDLINE]
Free PMC Article

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